Molecular Glue: Kinase Anchoring and Scaffold Proteins
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چکیده
منابع مشابه
Molecular Glue: Kinase Anchoring and Scaffold Proteins
This pathway proceeds from the membrane bound gua-nine nucleotide-binding protein Ras, through the se-Vollum Institute, Oregon Health Sciences University quential activation of the cytoplasmic serine/threonine Mail Code L474 kinases Raf, MAP-kinase kinase (MEK), and MAP kinase Portland Oregon, 97201–3098 (MAPK) and leads to specific gene expression in the nucleus. In the budding yeast S. cerevi...
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The process by which extracellular signals are relayed from the plasma membrane to specific intracellular sites is an essential facet of cellular regulation. Many signaling pathways do so by altering the phosphorylation state of tyrosine, serine, or threonine residues of target proteins. Recently, it has become apparent that regulatory mechanisms exist to influence where and when protein kinase...
متن کاملA-kinase-anchoring proteins.
Highly organized molecular complexes determine the precise location and timing of the signal transduction events that occur downstream of cell surface receptor activation (Pawson and Nash, 2003). One set of scaffolding molecules that organize such complexes is a family of proteins known as A-kinaseanchoring proteins (AKAPs). AKAPs provide a framework for the coordination of phosphorylation and ...
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Heart failure is a lethal disease that can develop after myocardial infarction, hypertension, or anticancer therapy. In the damaged heart, loss of function is mainly due to cardiomyocyte death and associated cardiac remodeling and fibrosis. In this context, A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that facilitate the spatiotemporal activation of the cyclic...
متن کاملA-kinase anchoring proteins: protein kinase A and beyond.
Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particularly in the field of t...
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ژورنال
عنوان ژورنال: Cell
سال: 1996
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81075-2